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treatment for Stress Urinary Incontinence
5 November 2021
Urinary Incontinence
Versameb present novel data VMB-100 as potential for treatment for Stress Urinary Incontinence

Versameb AG (“Versameb”), a pre-clinical stage company focused on discovering and developing innovative RNA-based drugs, today announces that its Chief Scientific Officer, Friedrich Metzger, will be presenting data on its mRNA engineering technology and lead therapeutic candidate, VMB-100 as a potential treatment for Stress Urinary Incontinence, at the 9th International mRNA Health Conference taking place on 9th and 10th November 2021 in Berlin.

Versameb has developed a groundbreaking RNA technology platform, VERSagile, and is building a pipeline of promising first-in-class RNA therapeutics. VMB-100 has demonstrated first-in-class potential for treatment for Stress Urinary Incontinence (SUI) in a pre-clinical animal model showing regeneration and functional restoration of the urinary sphincter.

Friedrich Metzger, Chief Scientific Officer, said: “Our findings indicate that local injection of our engineered mRNA results in therapeutically relevant target protein expression and secretion in muscle tissue, leading to muscle tissue regeneration. The regenerative effects seen following a single local injection support its therapeutic potential in muscle-related disorders such as stress urinary incontinence through restoration of muscle function.”

Presentation title: Regeneration of muscle tissue and function in Stress Urinary Incontinence using engineered RNA
Authors: Friedrich MetzgerJustin Antony Selvaraj, Claudia Bohnert, Nicole Stiffler, Pascale Birrer, Sina Zimmerli, Isabelle Kappeler, Tatsuo Satoh, Petra Hillmann, Isabel Ferreira, Klaas Zuideveld
Date & Time: Wednesday, 10 November, 10:40am – 10:55am CET during Session V: Therapeutics

Up to 50% of adult women suffer from SUI with no drug treatment currently approved. While behavioral and surgical interventions do exist, most are not effective in the long term.

Klaas Zuideveld, Chief Executive Officer, said: “We are delighted to be presenting our findings at this prestigious conference. In the past year, the tremendous potential of mRNA has been shown through the COVID-19 vaccines. Versameb’s VERSagile platform has the potential to yield first-in-class RNA therapeutics for disease indications with high unmet need.”

Read more news from The Bladder Interest Group here

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